Caldesmon Recombinant Antibody / CALD1 / CAD (HMW)

Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120-150kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70-80kDa) is found in non- muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This MAb recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction.

Q05682

Mouse

Recombinant full-length human CALD1 protein was used as the immunogen for the recombinant Caldesmon antibody.

Monoclonal

IgG1 κ

Recombinant

WB, IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Aliquot the recombinant Caldesmon antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This recombinant Caldesmon antibody is available for research use only.