Splicing factor 3B subunit 1 Antibody / SF3B1

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].

O75533

Rabbit

A portion of amino acids 374-402 from the human protein was used as the immunogen for the Splicing factor 3B subunit 1 antibody.

Polyclonal

Ig

IHC-P, WB

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the Splicing factor 3B subunit 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Splicing factor 3B subunit 1 antibody is available for research use only.