PPAR delta Antibody / PPARD

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that can be activated by a variety of compounds including fibratus, thiazolidinediones, prostaglandins and fatty acids. Three PPAR subtypes, designated PPARa, PPARb (also designated PPARd and PPARdelta) and PPARg, have been described. PPARs promote transcription by forming heterodimers with members of the retinoid X receptor (RXR) family of steroid receptors and binding to specific DNA motifs termed PPAR-response elements (PPREs). PPARa is abundant in primary hepatocytes, where it regulates the expression of proteins involved in fatty acid metabolism. PPARb is the most widely distributed subtype and is often expressed at high levels. PPARg is predominantly seen in adipose tissue, where it plays a critical role in regulating adipocyte differentiation. Interestingly, both the orphan nuclear hormone receptor LXRa and thyroid receptor (TR) have been shown to act as antagonists of PPARa/ RXRa binding to PPREs.

Q03181

Mouse

A recombinant partial protein sequence (within amino acids 72-146) from the human protein was used as the immunogen for the PPAR delta antibody.

Monoclonal

IgG2a

FACS

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Aliquot the PPAR delta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This PPAR delta antibody is available for research use only.