CD8 is a cell surface receptor expressed either as a heterodimer with the beta chain or as a homodimer. A majority of thymocytes and a subpopulation of mature Tcells and NK cells express CD8a. It binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in Tcell development and activation of mature Tcells. For mature Tcells, CD8 and 4 are mutually exclusive, so antibody to CD8 is generally used in conjunction with antibody to CD4. CD8a antibody is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral Tcell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+/CD8-, and in T-lymphoblastic lymphoma/leukemia, they are often co-expressed. It is also found in littoral cell angioma of the spleen.

P01732

Human recombinant protein was used as the immunogen for this CD8a antibody.

IHC-P, IF

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Store the CD8a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This CD8a antibody is available for research use only.

https://www.nsjbio.com/get_image.php?catalog_no=V2043-100UG&type=image1

https://www.nsjbio.com/tds-pdf/cd8a-antibody-c8468-v2043