Caspase-3 Antibody (phospho-S12)

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq].

P70677

Rabbit

This phospho-Caspase-3 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS12 of mouse CASP3.

Polyclonal

Ig

DB, ELISA

Antigen affinity purified

In 1X PBS pH 7.4 with 0.09% sodium azide

Aliquot the phospho-Caspase-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This phospho-Caspase-3 antibody is available for research use only.