C1QA Antibody / Complement C1q A-Chain

C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.

P02745

Mouse

A recombinant human partial protein (amino acids 104-237) was used as the immunogen for the Complement C1q A-Chain antibody.

Monoclonal

IgG2b κ

IHC-P

Purified

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Store the Complement C1q A-Chain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Complement C1q A-Chain antibody is available for research use only.