Desmin Antibody (Muscle cell marker)

Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain a-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

P17661

Mouse

Recombinant human Desmin was used as the immunogen for the Desmin antibody.

Monoclonal

IgG1 κ

IF, FACS, WB, IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the Desmin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Desmin antibody is available for research use only.