CD59 Antibody

CD59 is a glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, it can prevent C9 from polymerizing and forming the complement membrane attack complex. Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria. Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement. [Wiki]

P13987

Mouse

Recombinant full-length human protein was used as the immunogen for the CD59 antibody.

Monoclonal

IgG1 κ

IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Store the CD59 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This CD59 antibody is available for research use only.