Bcl-2 Antibody Cocktail

B-cell lymphoma 2 is an oncogene that regulates apoptosis, having both inducing and inhibiting functions. In cancer cells, Bcl2 binds pro-apoptotic proteins, preventing programmed cell death from occurring. Overexpression is seen in many cancers including lung, breast, prostate and lymphomas. In most follicular lymphomas, neoplastic germinal centers express high levels of the protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, Bcl2 antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies.

Mouse

A synthetic peptide, aa 41-54 (GAAPAPGIFSSQPG) of the human protein was used as the immunogen for both antibodies in this Bcl2 antibody cocktail.

Monoclonal

IgG1 κ

FACS, IF, WB, IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the Bcl2 antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Bcl2 antibody cocktail is available for research use only.