Leptin Receptor Antibody

Leptin, an adipocyte-specific hormone, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure by acting through the leptin receptor (LEPR). LEPR is a single-transmembrane-domain receptor of the cytokine receptor family that is identical to the mouse diabetes (db) gene product. During weight loss, leptin levels decrease, whereas soluble LEPR levels and the receptor bound fraction of leptin increases. The presence of LEPR in the absorptive cells of the small intestine suggests that leptin may have a physiological role in the regulation of nutrient absorption.

P48357

Rabbit

A portion of amino acids 23-52 from the human protein was used as the immunogen for this Leptin Receptor antibody.

Polyclonal

Ig

WB, FACS, IHC, ELISA

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the Leptin Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Leptin Receptor antibody is available for research use only.