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CCL23 Antibody / MPIF-1

CAT:V4466-100UGSize:100 µgPrice:Ask for quotation

Availability:

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Shipping:

This product ships with dry ice.

Description:

Small inducible cytokine A23 precursor (CCL23), also called CK-b-8 and Myeloid Progenitor Inhibitory Factor 1 (MPIF-1), is a chemokine that binds to the receptor CCR1. It is involved in the immune response and inhibits production of polymorphonuclear leukocytes (PMNs) and monocytes in bone marrow. In addition, CCL23 has a splice variant, CK-b-8-1, and both variants chemoattract lymphocytes, monoctyes and neutrophils. CCL23 also promotes angiogenesis and endothelial cell migration via its actions on the CCR1 receptor. Proinflammatory proteases cleave an N-terminal domain of CCL23, improving the potency of its CCR1-mediated signaling up to 1000- fold in vitro. N-truncated CCL23 is found in high levels in synovial fluids of rheumatoid arthritis patients, suggesting a role of protease release during an inflammatory response. High levels of CCL23 mRNA expression occur in human fetal bone osteoblasts and chondrocytes, indicating a possible role for CCL23 in the recruitment of osteoclast precursors to the sites of bone reabsorption.

UniProt:

P55773

Host:

Mouse

Immunogen:

A recombinant partial protein sequence (within amino acids 1-120) from the human protein was used as the immunogen for the CCL23 antibody.

Clonality:

Monoclonal

Isotype:

IgG2a κ

Applications:

IHC-P

Format:

Purified

Buffer:

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution:

Aliquot the Myeloid Progenitor Inhibitory Factor 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations:

This CCL23 antibody is available for research use only.

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