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E-Cadherin Recombinant Antibody / CDH1

CAT:V8662SAF-100UGSize:100 µgPrice:Ask for quotation

Availability:

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Shipping:

This product ships with dry ice.

Description:

E-cadherin is a transmembrane, calcium dependent cell adhesion protein that mediates cell to cell adhesion and maintains structural and functional integrity of epithelial tissues. It also has pivotal barrier functions and maintains the polarity of epithelial cells. Reduced or aberrant E-cadherin expression breaks cell to cell contacts, and thus, cells acquire the ability to migrate. In normal tissues, immunostaining of E-cadherin is localized to the membrane of epithelial cells, consistent with its role in cell adhesion. And in tumor tissues, E-cadherin stains positively in glandular epithelium as well as adenocarcinomas of the lung, gastrointestinal tract, and ovary. It has also been shown to be positive in some thyroid carcinomas. A combination of E-cadherin and p120 catenin may help distinguish ductal carcinoma of the breast from lobular carcinoma. And also, several studies have reported that reduced E-cadherin expression is correlated with poor prognosis in several types of carcinomas.

UniProt:

P12830

Host:

Rabbit

Immunogen:

A portion of amino acids 600-700 from the human protein was used as the immunogen for the recombinant E-Cadherin antibody.

Clonality:

Monoclonal

Isotype:

IgG

Type:

Recombinant

Applications:

IHC-P

Format:

Purified

Buffer:

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution:

Store the recombinant E-Cadherin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations:

This recombinant E-Cadherin antibody is available for research use only.

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