Beclin 1 Antibody

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Beclin 1 plays a role in two fundamentally important cell biological pathways: autophagy and apoptosis. Beclin 1 is thought to function as a VPS and autophagy protein as part of a complex with Class III PI3 kinase, Vps34.

Q14457

Rabbit

A portion of amino acids 181-210 from the human protein was used as the immunogen for this Beclin 1 antibody.

Polyclonal

Ig

WB, IHC, ELISA

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the Beclin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Beclin 1 antibody is available for research use only.