Rb Antibody

The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in many types of cancer. One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer. Retinoblastoma (Rb) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral.

P06400

Rabbit

A portion of amino acids 586-615 from the human protein was used as the immunogen for this Rb antibody.

Polyclonal

Ig

IHC, WB, IF, ELISA

Antigen affinity purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the Rb antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Rb antibody is available for research use only.