BCMA Recombinant Antibody / CD269 / TNFRSF17

The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).

Q02223

Rabbit

A recombinant human protein fragment (within amino acids 1-184) was used as the immunogen for the B-cell maturation protein antibody.

Monoclonal

IgG κ

Recombinant

ELISA, IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Aliquot the B-cell maturation protein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This B-cell maturation protein antibody is available for research use only.