Estrogen Receptor alpha Recombinant Antibody

Recognizes a protein of 67kDa, which is identified as estrogen receptor (ER) alpha. The ER gene consists of more than 140kb of genomic DNA divided into 8 exons, being translated into a protein with six functionally discrete domains, labeled A through F. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas.The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to antiestrogen (e.g. tamoxifen) therapy.

P03372

Mouse

A recombinant fragment corresponding to the C-terminus of human ER-alpha was used as the immunogen for the Estrogen Receptor alpha antibody.

Monoclonal

IgG2b κ

Recombinant

IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Aliquot the Estrogen Receptor alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Estrogen Receptor alpha antibody is available for research use only.