Anti-SOCS3 Purified

SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.

The antibody SO1 reacts with SOCS3, an intracellular cytokine signaling inhibitor.

RUO

Mouse

Human

Full-length SOCS3 protein.

SOCS3

IgG2b

SO1

Western blotting: Positive control: HeLa human cervix carcinoma cell line, reducing conditions.

WB

1 mg/mL

Purified

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

*Neuwirt H, Puhr M, Cavarretta IT, Mitterberger M, Hobisch A, Culig Z: Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion. Endocr Relat Cancer. 2007 Dec14(4):1007-19., URL: http://www.ncbi.nlm.nih.gov/pubmed/18045952,

*Miao T, Wu D, Zhang Y, Bo X, Xiao F, Zhang X, Magoulas C, Subang MC, Wang P, Richardson PM: SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase. Mol Cell Neurosci. 2008 Feb37(2):367-75., URL: https://www.ncbi.nlm.nih.gov/pubmed/18055217?ordin,*Elliott J: SOCS3 in Liver Regeneration and Hepatocarcinoma. Mol Interv. 2008 Feb8(1):19-21., URL: https://www.ncbi.nlm.nih.gov/pubmed/18332480?ordin,*Zhu BM, Ishida Y, Robinson GW, Pacher-Zavisin M, Yoshimura A, Murphy PM, Hennighausen L. SOCS3 Negatively Regulates the gp130-STAT3 Pathway in Mouse Skin Wound Healing. J Invest Dermatol. 2008 Jan 10, URL: https://www.ncbi.nlm.nih.gov/pubmed/18185532?ordin,*Kimura A, Kinjyo I, Matsumura Y, Mori H, Mashima R, Harada M, Chien KR, Yasukawa H, Yoshimura A. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem. 2004 Feb 20279(8):6905-10., URL: https://www.ncbi.nlm.nih.gov/pubmed/14699146?ordin,*Yu CR, Mahdi RM, Ebong S, Vistica BP, Gery I, Egwuagu CE: Suppressor of cytokine signaling 3 regulates proliferation and activation of T-helper cells. J Biol Chem. 2003 Aug 8278(32):29752-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/12783879?ordin,

Store at 2-8°C. Do not freeze.