CRBN antibody

Substrate recognition component of a DCX(DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.

Protein cereblon|CRBN

51185

Q96SW2

Rabbit

Human, Mouse, Rat

cereblon

CRBN

Polyclonal

IgG

ELISA, WB, IHC

Metabolism

Immunogen affinity purified

WB: 1:500-1:2000; IHC: 1:50-1:200

≥95% as determined by SDS-PAGE

Liquid

53 kDa

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Primary Antibodies

https://www.fn-test.com/product/FNab01954/

Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using FNab01954(CRBN Antibody) at dilution of 1:200

mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab01954 (CRBN antibody) at dilution of 1:1000