NCK1 antibody

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors.

SH2/SH3 adapter protein NCK1|Cytoplasmic protein NCK1|NCK adapter protein 1 (Nck-1)|SH2/SH3 adapter protein NCK-alpha|NCK1|NCK

4690

P16333

Rabbit

Human, Mouse, Rat

NCK adaptor protein 1

NCK1

Polyclonal

IgG

ELISA, WB, IHC, IF, FC, IP

Immunology, Cardiovascular, Developmental biology, Signal Transduction

Immunogen affinity purified

WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200

≥95% as determined by SDS-PAGE

Liquid

43 kDa

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Primary Antibodies

https://www.fn-test.com/product/FNab05583/

Immunohistochemistry of paraffin-embedded human breast cancer using FNab05583(NCK1 antibody) at dilution of 1:100

mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab05583 (NCK1 antibody) at dilution of 1:400