TAP1 antibody

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Antigen peptide transporter 1 (APT1)|ATP-binding cassette sub-family B member 2|Peptide supply factor 1|Peptide transporter PSF1 (PSF-1)|Peptide transporter TAP1|Peptide transporter involved in antigen processing 1|Really interesting new gene 4 protein (RING4)|TAP1|ABCB2|PSF1|RING4|Y3

6890

Q03518

Rabbit

Human, Mouse

transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)

TAP1

Polyclonal

IgG

ELISA, IF, WB, IHC, IP

Immunology

Immunogen affinity purified

WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

≥95% as determined by SDS-PAGE

Liquid

70-81 kDa

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Primary Antibodies

https://www.fn-test.com/product/FNab08499/

Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using FNab08499(TAP1 Antibody) at dilution of 1:50

https://www.fn-test.com/content/uploads/product/images/antibody4/FNab08499.jpg

HepG2 cells were subjected to SDS PAGE followed by western blot with FNab08499 (TAP1 Antibody) at dilution of 1:1000

https://www.fn-test.com/content/uploads/product/images/antibody1/FNab08499.jpg