TSHR antibody

The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. The gene of TSHR maps to chromosome 14q31.1, and encodes a 764-amino acid protein with a predicted unmodified molecular weight of 86.8 kDa. The apparent molecular weight of glycosylated form is 95-120 kDa. Studies reveal that TSHR is composed of two subunits, A and B, which are produced by cleavage of single-chain TSHR on the cell surface and subsequently connected by disulfide bonds. This rabbit polyclonal antibody can detect glycosylated subunit A with an experimentally determined molecular weight of 62-70 kDa under reducing condition. (PMID: 20578897, 17158770, 12593718)

Thyrotropin receptor|Thyroid-stimulating hormone receptor (TSH-R)|TSHR|LGR3

7253

P16473

Rabbit

Human, Mouse, Rat

thyroid stimulating hormone receptor

TSHR

Polyclonal

IgG

ELISA, WB, IHC, IF

Cancer, Signal Transduction

Immunogen affinity purified

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20- 1:50

≥95% as determined by SDS-PAGE

Liquid

62-100 kDa

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Primary Antibodies

https://www.fn-test.com/product/FNab09045/

Immunohistochemistry of paraffin-embedded rat brain using FNab09045(TSHR antibody) at dilution of 1:100

HeLa cells were subjected to SDS PAGE followed by western blot with FNab09045 (TSHR antibody) at dilution of 1:1000