Choline Acetyltransferase Antibody: ATTO 594

Acetylcholine (ACh) is a common neurotransmitter for motoneurons, preganglionic autonomic neurons, postganglionic parasympathetic neurons, a variety of brain regions and some emerging neuron-like stem cells. The metabolism of Ach is relatively simple, involving only two enzymes: choline acetyltransferase (ChAT) for synthesis and acetylcholinesterase (AChE) for degradation. Further, acetylcholine has little function in neurons other than neurotransmission and seems to be neuron specific. It seems that only cholinergic neurons have significant amounts of ChAT making anti-choline acetyltransferase a useful specific marker. ChAT is a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease and Down syndrome (1-3).

Rabbit Anti-Human Choline Acetyltransferase Polyclonal

Predicted molecular weight at ~82.5kDa. Observed molecular weights between 68-70kDa.

Neuroscience, Neurotransmission, Neurotransmitter Receptors, Cell Signaling, Neurodegeneration, Alzheimer's Disease

12352203

1103

P28329

NP_001136401.1

Cytoplasm | Cytosol | Mitochondrion | Nucleus

Rabbit

Human, Mouse

Synthetic peptide from the N-terminal to the mid-protein of human Choline O-Acetyltrasferase

Choline Acetyltransferase

Polyclonal

ATTO 594

IHC, ICC/IF

Peptide Affinity Purified

1 mg/ml

WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

0.1

640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

1. Houser C.R., Crawford G.D., Barber R.P., Salvaterra P.M., Vaughn J.E. (1983) Brain Research. 266(1): 97-119.
2. Karson C.N., Casanova M.F., Kleinman J.E.m Griffin W.S. (1993) Am J Psychiatry. 150: 454-459.
3. Baskins D.S., et al. (1999) Arch Neurol. 56: 1121-1123.

Antibodies

Polyclonal

https://www.stressmarq.com/products/antibodies/choline-acetyltransferase-antibody-spc-706/

Canada