UVRAG Antibody: PerCP

Rabbit Anti-Human UVRAG Polyclonal

UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (1). Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (2). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (3-4). It is highly expressed in the brain, lung, kidney and liver.

Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.

Cancer, Apoptosis, Autophagy, Cell Signaling, Epigenetics and Nuclear Signaling, Cardiovascular System, Heart

12352203

7405

Q9P2Y5

NP_003360.2

Endosome | Lysosome | Endoplasmic reticulum | Nucleus | Chromosome | Centromere

Rabbit

Human, Mouse, Rat

Synthetic peptide from the mid-protein of human UVRAG

UVRAG

Polyclonal

PerCP

WB, IHC, ICC/IF, ELISA

Peptide Affinity Purified

1 mg/ml

WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

0.1

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

1. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87.
2. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87.
3. Ionov, Y. et al. (2004) Oncogene. 23: 639-45.
4. Kim, M.S. et al. (2008) Hum Pathol. 39: 1059-63.

Antibodies

Polyclonal

https://www.stressmarq.com/products/antibodies/uvrag-antibody-spc-606/

Canada