Anti-GLUT-1 (Tumor Progression and Mesothelioma Marker)(rGLUT1/2476), CF740 conjugate

Recognizes a protein of 55 kDa, which is identified as GLUT-1. Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. There are many types of glucose transport carrier proteins, designated as Glut-1 to Glut-12. Glut-1 is a major glucose transporter in the mammalian blood-brain barrier. It is expressed in high density on the membranes of human erythrocytes and the brain capillaries that comprise the blood-brain barrier. Glut-1 is expressed at variable levels in many human tissues. Overexpression of Glut-1 has been linked to tumor progression or poor survival of patients with carcinomas of the colon, breast, cervical, lung, bladder and mesothelioma. Glut-1 is a sensitive and specific marker for the differentiation of malignant mesothelioma (positive) from reactive mesothelium (negative). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Erythrocyte/hepatoma glucose transporter; Glucose transporter type-1; GLUT1; GLUT1DS; GLUTB; GT1; GTG1; Gtg3; HepG2 glucose transporter; PED; RATGTG1; Solute carrier family 2; Solute carrier family 2; facilitated glucose transporter member 1 (SLC2A1)

41116161

Primary and secondary antibodies for multiple methodology
immunostaining detection application

SLC2A1

6513

473721

P11166

Plasma membrane

Mouse

Human

Recombinant fragment of human GLUT1 protein (around aa 203-305) (exact sequence is proprietary)

GLUT-1

Recombinant Monoclonal

IgG1 κ

rGLUT1/2476

CF740

Tumor

Animal

IHC, FFPE (verified)

IHC, FFPE

K562, A431, MDA-MB-231 cells or erythrocytes. Mesothelioma or breast, colon and ovarian carcinoma.

0.1 mg/mL

PBS, 0.1% rBSA, 0.05% azide

55 kDa

Room temperature

4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

2 years

Primary

https://biotium.com/product/glut-1-recombinant-monoclonal-mouse-antibody-rglut1-2476