Anti-Cadherin 17 / LI Cadherin (Liver-Intestine Marker)(CDH17/2618), CF568 conjugate

Cadherin 17, also known as LI cadherin (for liver-intestine cadherin), is a member of the cadherin family of calcium-dependent adhesion molecules. Cadherins mediate cell-cell interactions via hemophilic binding, and are critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. Cadherin 17 expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Cadherin 17; Cadherin-17; CDH17; LI-cadherin; Liver-intestine cadherin; human peptide transporter 1 (HPT-1); Intestinal peptide-associated transporter HPT-1

41116161

Primary and secondary antibodies for multiple methodology
immunostaining detection application

CDH17

1015

591853

Q12864

Plasma membrane

Mouse

Human

Recombinant fragment (around aa 242-418) of human Cadherin 17 protein (CDH17) (exact sequence is proprietary)

Cadherin 17 | LI Cadherin

Monoclonal

IgG2b κ

CDH17/2618

CF568

Animal

Flow (verified) | IHC, FFPE (verified)

FC, IHC, FFPE

Cell adhesion

MCF-7, HepG2 or HT29 cells. Stomach, Small Intestine, Colon or liver.

0.1 mg/mL

PBS, 0.1% BSA, 0.05% azide

120 kDa

Room temperature

4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

2 years

Primary

https://biotium.com/product/cadherin-17-li-cadherin-monoclonal-mouse-antibody-cdh17-2618