Anti-PD-L2 / PDCD1LG2 / CD273(PDL2/2676), CF740 conjugate

Recognizes a protein of about 31 kDa, which is identified as PD-L2 (same as PDCD1LG2). Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. PD-L2 does not bind CD28, cytotoxic T lymphocyte A4 or ICOS (inducible co-stimulator). The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

B7 dendritic cell molecule; B7-DC; B7DC; Btdc; Butyrophilin B7DC; CD273; PD-L2; PDCD1L2; PDCD1LG2; PDL2; Programmed death ligand 2

41116161

Primary and secondary antibodies for multiple methodology
immunostaining detection application

PDCD1LG2

80380

532279; 617872

Q9Q51

Plasma membrane

Mouse

Human

Recombinant fragment (around aa 27-220) of human PD-L2 protein (exact sequence is proprietary)

CD273 | PD-L2 | PDCD1LG2

Monoclonal

IgG1 κ

PDL2/2676

CF740

Animal

Flow (verified) | IF (verified) | WB (verified)

FC, IF, WB

Jurakt, HepG2, THP-1, RAW, NIH3T3, U87 cells Placenta or Pancreas. Thyroid Carcinoma.

0.1 mg/mL

PBS, 0.1% rBSA, 0.05% azide

31 kDa

Room temperature

4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

2 years

Primary

https://biotium.com/product/pd-l2-pdcd1lg2-cd273-monoclonal-mouse-antibody-pdl2-2676