CLC-4 rabbit pAb

Chloride voltage-gated channel 4 (CLCN4) Homo sapiens The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22. 3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012],

CLCN4; H(+)/Cl(-) exchange transporter 4; Chloride channel protein 4; ClC-4; Chloride transporter ClC-4

1183

P51793

Early endosome membrane ; Multi-pass membrane protein. Late endosome membrane ; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein. Lysosome membrane ; Multi-pass membrane protein. Recycling endosome membrane ; Multi-pass membrane protein. Localizes to late endosome membrane, lysosome membrane and recycling endosome membrane in the presence of CLCN3..

Rabbit

Human, Mouse, Rat

The antiserum was produced against synthesized peptide derived from human CLCN4. AA range:221-270

Polyclonal

WB, IF, ELISA

1 year

1 mg/mL

Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

85kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.