CYFIP2 rabbit pAb

Disease: Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level). function: Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA. induction: By p53. RNA editing: Partially edited. Editing appears to be brain-specific. similarity: Belongs to the CYFIP family. subcellular location: Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus. subunit: Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.

Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)

26999

Q96F07

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118)..

Rabbit

Human, Mouse, Rat

Synthesized peptide derived from CYFIP2 at AA range: 1171-1220

Polyclonal

WB, ELISA

1 year

1 mg/mL

WB 1:500-2000, ELISA 1:10000-20000

150+45kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.