Anti-Calpain 1(CAPN1/1530), CF740 conjugate

Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2 - dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Calpain 1; Calcium dependent protease small subunit 1; Calcium-activated neutral proteinase 1; Calpain 1 large subunit; Calpain mu-type; Calpain-1 catalytic subunit; CANP1; CANPL1; CAPN1

41116161

Primary and secondary antibodies for multiple methodology
immunostaining detection application

CAPN1

823

502842

P07384

Cytoplasmic|Plasma membrane

Mouse

Human

Recombinant full-length human CAPN1 protein

Calpain 1

Monoclonal

IgG1 κ

CAPN1/1530

CF740

Animal

IHC, FFPE (verified)

IHC, FFPE

Cytoskeleton

HeLa cells. Skin or Tonsil.

0.1 mg/mL

PBS, 0.1% rBSA, 0.05% azide

~80 kDa

Room temperature

4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

2 years

Primary

https://biotium.com/product/alk-cd246-monoclonal-mouse-antibody-alk-1504