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Anti-Calpain 1(CAPN1/1530), CF740 conjugate
Calpain 1 is an intracellular calcium-dependent protease that cleaves cytoskeletal and sub-membranous proteins. Calpains are non-lysosomal, calcium-activated intracellular cysteine proteases. Calpains mediate specific Ca2 - dependent processes including cell fusion, mitosis and meiosis. Calpains are heterodimers of a small regulatory subunit and one of three large catalytic subunits, designated Calpain 1, Calpain 2 and Calpain p94. Calpastatin regulates Calpain by inhibiting both the proteolytic activity of Calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing. Calpain 1 co-localizes with human leukocyte antigen-DR (HLA-DR) on activated microglia in the aging brain. Calpain influences the process of spermatogenesis and the events preceding fertilization, such as the acrosome reaction. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Calpain 1; Calcium dependent protease small subunit 1; Calcium-activated neutral proteinase 1; Calpain 1 large subunit; Calpain mu-type; Calpain-1 catalytic subunit; CANP1; CANPL1; CAPN1
41116161
Primary and secondary antibodies for multiple methodology
immunostaining detection application
CAPN1
823
502842
P07384
Cytoplasmic|Plasma membrane
Mouse
Human
Recombinant full-length human CAPN1 protein
Calpain 1
Monoclonal
IgG1 κ
CAPN1/1530
CF740
Animal
IHC, FFPE (verified)
IHC, FFPE
Cytoskeleton
HeLa cells. Skin or Tonsil.
0.1 mg/mL
PBS, 0.1% rBSA, 0.05% azide
~80 kDa
Room temperature
4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
2 years
Primary
https://biotium.com/product/alk-cd246-monoclonal-mouse-antibody-alk-1504
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