DHRS4 rabbit pAb

Catalytic activity: R-CHOH-R' + NADP (+) = R-CO-R' + NADPH. function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones. miscellaneous: Inhibited by kaempferol, quercetin, genistein and myristic acid. similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. subcellular location: Isoform 1 is peroxisomal, while isoform 4 is not. subunit: Homotetramer. tissue specificity: Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoforms 5 and 6 are expressed in a few neoplastic cervical tissues.

DHRS4; Dehydrogenase/reductase SDR family member 4; NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; CR; PHCR; NADPH-dependent retinol dehydrogenase/reductase; NRDR; humNRDR; Peroxisomal short-chain alcohol dehydrogenase; PSCD

10901

Q9BTZ2

[Isoform 1]: Peroxisome. Isoform 4 is not peroxisomal..; [Isoform 7]: Nucleus.

Rabbit

Human, Rat, Mouse,

The antiserum was produced against synthesized peptide derived from human DHRS4. AA range:191-240

Polyclonal

WB, IHC, IF, ELISA

1 year

1 mg/mL

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

32-34kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.