Anti-DNMT1 / DNA Methyltransferase 1(DNMT1/2061), CF640R conjugate

This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

ADCADN; AIM; CXXC-type zinc finger protein 9; CXXC9; DNA methyltransferase 1 (DNMT1); HSN1E; MCMT; Met1; MommeD2

41116161

Primary and secondary antibodies for multiple methodology
immunostaining detection application

DNMT1

1786

202672

P26358

Nucleus

Mouse

Human

Recombinant human DNMT1 protein fragment (around aa 767-912) (exact sequence is proprietary)

DNA Methyltransferase 1 | DNMT1

Monoclonal

IgG2b κ

DNMT1/2061

CF640R

Animal

IHC, FFPE (verified)

IHC, FFPE

Raji cells. Tonsil or Placenta.

0.1 mg/mL

PBS, 0.1% BSA, 0.05% azide

184 kDa

Room temperature

4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

2 years

Primary

https://biotium.com/product/dnmt1-dna-methyltransferase-1-monoclonal-mouse-antibody-dnmt1-2061