DOCK 180 rabbit pAb

This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014],

DOCK1; Dedicator of cytokinesis protein 1; 180 kDa protein downstream of CRK; DOCK180

1793

Q14185

Cytoplasm. Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate..

Rabbit

Human, Mouse

The antiserum was produced against synthesized peptide derived from human DOCK1. AA range:1661-1710

Polyclonal

WB, ELISA

1 year

1 mg/mL

Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

215kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.