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eIF2α rabbit pAb

CAT:ES2244-02Size:100 μLPrice:Ask for quotation

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description:

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al. 1987 [PubMed 2948954]). [supplied by OMIM, Feb 2010],

Synonyms:

EIF2S1; EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha

Gene ID:

1965

UniProt:

P05198

Cellular Locus:

Cytoplasm, Stress granule. Colocalizes with NANOS3 in the stress granules..

Host:

Rabbit

Species Reactivity:

Human, Mouse, Rat, Monkey, Fish

Immunogen:

The antiserum was produced against synthesized peptide derived from human eIF2 alpha. AA range:21-70

Clonality:

Polyclonal

Validated Applications:

IF, WB, IHC, ELISA

Stability:

1 year

Concentration:

1 mg/mL

Dilution:

IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight:

38kD

Storage Conditions:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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Product Datasheet:

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