Ferrostatin-1

Ferrostatin-1 inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death. It is especially potent of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices (1). It also blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells (2), and inhibits oxidative lipid damage and cell death in diverse disease models (3). It has also been shown to mitigate rotenone-induced a-synuclein aggregation (4).

Ferroptosis Inhibitor

Ethyl 3-amino-4-(cyclohexylamino)benzoate

347174-05-4

41116105

Synthetic

>98% (TLC); NMR (Conforms)

0.025

Tan powder

Soluble in DMSO (100 mg/ml) or ethanol (100 mg/ml)

C15H22N2O2

262.4

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

1. Dixon S.J., et al. (2012) Cell. 149: 1060.
2. Louandre C., et al. (2013) Int. J. Cancer. 133: 1732.
3. Skouta R., et al. (2014) J. Am. Chem. Soc. 136: 4551. 4. P Kabiraj et al; Protein J., 2015 34; 349

Small Molecules

Inhibitor

https://www.stressmarq.com/products/small-molecules/ferrostatin-1-sih-525/

Canada