JC-1

Mitochondrial membrane-potential dependent fluorescent dye

JC-1 is a fluorescent dye that is able to pass across the mitochondrial membrane. It is used to measure mitochondrial membrane potential. At low membrane potentials, it remains a monomer and emits green-fluorescent light (λex=485 nm, λem=520 nm). At higher membrane potentials, it forms "J-aggregates", which emit red-fluorescent light (λex=520-570 nm, λem=570-610 nm). The ratio of red/green fluorescence is based only on the membrane potential, and not on mitochondrial size, shape or density.

5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide, , 5,6-dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl)prop-2-enylidene]-1,3-diethylbenzimidazole;iodide, Jc-1; 3520-43-2; JC-1 jodide; JC1 dye; CBIC2(3); 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide

3520-43-2

41116105

Synthetic

>98% (HPLC); NMR (Conforms)

0.005

Red powder

May be dissolved in DMSO (20 mg/ml)

C25H27Cl4IN4

652.2

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Small Molecules

Membrane Potential Probe

https://www.stressmarq.com/products/small-molecules/jc-1-sih-562/

Canada