LGR5 Antibody (GPR49)

LGR5/GPR49 is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. [UniProt]

O75473

Rabbit

A portion of amino acids 605-638 from the human protein was used as the immunogen for this anti-LGR5 antibody.

Polyclonal

Ig

IHC, WB, ELISA

Purified

In 1X PBS pH 7.4 with 0.09% sodium azide

Aliquot the anti-LGR5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This anti-LGR5 antibody is available for research use only.

Primary antibody

https://www.nsjbio.com/tds/anti-lgr5-antibody-f48167