MARCH1 rabbit pAb

MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6. 3. 2. 19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al. 2004 [PubMed 14722266]; Thibodeau et al. 2008 [PubMed 18389477]; De Gassart et al. 2008 [PubMed 18305173]). [supplied by OMIM, Mar 2010],

MARCH1; RNF171; E3 ubiquitin-protein ligase MARCH1; Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; MARCH-I; RING finger protein 171

55016

Q8TCQ1

Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein. Lysosome membrane ; Multi-pass membrane protein. Cytoplasmic vesicle membrane ; Multi-pass membrane protein. Late endosome membrane ; Multi-pass membrane protein. Early endosome membrane ; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein.

Rabbit

Human,Rat,Mouse,

Synthesized peptide derived from the Internal region of human 40603.

Polyclonal

IHC,IF,WB,ELISA

1 year

1 mg/mL

WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

32kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.