MARCH2 rabbit pAb

MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6. 3. 2. 19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al. 2004 [PubMed 14722266]; Nakamura et al. 2005 [PubMed 15689499]). [supplied by OMIM, Mar 2010],

MARCH2; RNF172; HSPC240; E3 ubiquitin-protein ligase MARCH2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; MARCH-II; RING finger protein 172

51257

Q9P0N8

Endoplasmic reticulum membrane ; Multi-pass membrane protein. Lysosome membrane ; Multi-pass membrane protein. Endosome membrane ; Multi-pass membrane protein. Golgi apparatus membrane ; Multi-pass membrane protein. Cytoplasm. Cell membrane ; Multi-pass membrane protein.

Rabbit

Human,Rat,Mouse,

The antiserum was produced against synthesized peptide derived from human MARCH2. AA range:191-240

Polyclonal

IHC,IF,ELISA

1 year

1 mg/mL

Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.