MCM6 rabbit pAb

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, i

MCM6; DNA replication licensing factor MCM6; p105MCM

4175

Q14566

Nucleus. Chromosome. Binds to chromatin during G1 and detach from it during S phase..

Rabbit

Human,Mouse,Rat

The antiserum was produced against synthesized peptide derived from the Internal region of human MCM6. AA range:331-380

Polyclonal

WB,IHC

1 year

1 mg/mL

WB 1:500-2000;IHC-p 1:50-300

90kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.