Anti-MUC4 (Mucin 4 / Gastric Mucin)(MUC4/3105), CF594 conjugate

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100%) and sensitive (90%) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; Ascites sialoglycoprotein; ASGP; ASGP-1; ASGP-2; Mucin 4 cell surface associated; Mucin-4 beta chain; Pancreatic adenocarcinoma mucin; Testis mucin; Tracheobronchial mucin

41116161

Primary and secondary antibodies for multiple methodology
immunostaining detection application

MUC4

4585

369646

Q99102

Plasma membrane

Mouse

Human

Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary)

MUC4

Monoclonal

IgG2b κ

MUC4/3105

CF594

Animal

IHC, FFPE (verified)

IHC, FFPE

Cancer, Mucins

Stomach, Colon or esophagus.

0.1 mg/mL

PBS, 0.1% BSA, 0.05% azide

235 kDa

Room temperature

4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

2 years

Primary

https://biotium.com/product/mucin-4-muc4-monoclonal-mouse-antibody-muc4-3105