Mycophenolate mofetil

Inosine monophosphate dehydrogenase inhibitor

Mycophenolate mofetil is an immunosuppressive agent useful in prevention of organ allograft rejection (1). It is metabolized to mycophenolic acid in vivo, which acts by inhibiting the biosynthesis of guanine nucleotides via inhibition of inosine 5’-monophosphate dehydrogenase, suppressing the production of proinflammatory cytokines, nitric oxide and LDH in macrophages (2,3). It also inhibits IL-2-dependent T cell proliferation (4), and microglial and astrocytic activation reducing cell death after neuronal injury (5). It also prevents neuroinflammation.

6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester

128794-94-5

41116105

Synthetic

>98% (TLC); NMR (Conforms)

0.005

White powder

May be dissolved in DMSO (40 mg/ml); or ethanol (4 mg/ml)

C23H31NO7

433.5

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

1. Allison A.C., and Eugui, E.M. (1996) Clin. Transplant. 10:77.
2. Jonsson C.A., et al., (2002) Cell. Immunol. 216:93.
3. Allison A.C., et al., (1993) Ann. NY Acad. Sci. 696:63.
4. Quemeneur J., et al., (2002) J. Immunol. 169:2747
5. Ebrahimi F., et al., (2012) J. Neuroinflammation 9:89.

Small Molecules

Inhibitor

https://www.stressmarq.com/products/small-molecules/mycophenolate-mofetil-sih-568/

Canada