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Org37684
No Development Reported
213007-95-5
Org37684 is a highly potent 5-HT2C receptor agonist (pEC50=8.17). Org37684 exhibits a rank order of potency of 5-HT2C>5-HT2B>5-HT2A. Its selectivity for the 5-HT2C receptor is approximately 2.5 times over the 5-HT2B (pEC50=7.96) and ten times for the 5-HT2A (pEC50=7.11) receptor[1].
5-HT Receptor
Reference compound
GPCR/G Protein;Neuronal Signaling
Neuroscience-Neuromodulation
Neurological Disease
https://www.medchemexpress.com/org37684.html
10 mM in DMSO
COC1=C(O[C@@H]2CNCC2)C3=C(CCC3)C=C1.[H]Cl
269.77
[1]Porter RH, et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br J Pharmacol. 1999;128(1):13-20.
Room temperature
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