p140Cap rabbit pAb

Function: Delays the onset of cell spreading in the early stages of cell adhesion to fibronectin. Also involved in calcium-dependent exocytosis from PC12 cells. PTM: Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands. similarity: Belongs to the p140Cap family. subcellular location: Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. subunit: Interacts with the N-terminal coiled-coil region of SNAP25 (By similarity). Interacts with BCAR1/p130Cas through its C-terminal domain.

SRCIN1; KIAA1684; P140; SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap

80725

Q9C0H9

Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density. Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions..

Rabbit

Human, Mouse, Rat

The antiserum was produced against synthesized peptide derived from human SNIP. AA range:811-860

Polyclonal

WB, ELISA

1 year

1 mg/mL

Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

112kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.