Phosphoserine Antibody

Rabbit Anti-Phosphoserine Polyclonal

Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a protein's activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine; others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time (1). Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders (2-4).

Detects proteins phosphorylated on serine residues. Does not cross-react with phosphotyrosine.

Cell Signaling, Post-translational Modifications, Phosphorylation

12352203

Rabbit

Species Independent

Phosphoserine conjugated to KLH, and phosvitin mixture

Phosphoserine

Polyclonal

Unconjugated

WB,IHC,ICC/IF,IP,ELISA

Peptide Affinity Purified

0.25 mg/ml

WB (1:500), ICC/IF (1:50), ELISA (1:250), IP (1:100); optimal dilutions for assays should be determined by the user.

0.4

PBS, 50% glycerol, 0.01% sodium azide *Storage buffer changes when conjugated

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

1. Goto H. et al. (2005) Nature Cell Biology 8: 180-187.
2. Blume-Jensen P. and Hunter T. (2001) Nature 411: 355-365.
3. Downward J. (2001) Nature 411: 759-762.
4. Pawson T. and Saxton T.M. (1999) Cell 97: 675-678.
5. Ostrovsky P.C. (1995) Genes Dev. 9(16): 2034-2041.