PLGF Antibody / PGF / Placenta Growth Factor

The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include fibroblast-, platelet derived-, vascular endothelial- and placenta- growth factor (PLGF). Like vascular endothelial growth factor, several PLGF variants have been shown to arise from alternative mRNA splicings. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.

Mouse

Recombinant human protein was used as the immunogen for this PLGF antibody.

Monoclonal

IgG1 κ

ELISA, Functional studies

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Store the PLGF antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This PLGF antibody is available for research use only.

Primary antibody

https://www.nsjbio.com/tds/plgf-antibody-plgf94-v2223