RAMP3 rabbit pAb

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008],

10268

O60896

Cell membrane ; Single-pass type I membrane protein. Membrane ; Single-pass type I membrane protein. Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Rabbit

Human,Rat,Mouse,

Synthesized peptide derived from part region of human protein

Polyclonal

WB,ELISA

1 year

1 mg/mL

WB 1:500-2000 ELISA 1:5000-20000

16kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.