SLU7 rabbit pAb

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008],

SLU7; Pre-mRNA-splicing factor SLU7; hSlu7

10569

O95391

Nucleus. Nucleus speckle. Cytoplasm. Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules..

Rabbit

Human, Mouse, Rat

The antiserum was produced against synthesized peptide derived from human SLU7. AA range:113-162

Polyclonal

WB, IHC

1 year

1 mg/mL

WB 1:500-2000;IHC-p 1:50-300

65kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.