SOX4 Antibody

SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF-β-induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival in vitro and for primary tumor growth and metastasis in vivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.

Q06945

Mouse

Full length recombinant human protein was used as the immunogen for the SOX4 antibody.

Monoclonal

IgG2b κ

IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Store the SOX4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This SOX4 antibody is available for research use only.

Primary antibody

https://www.nsjbio.com/tds/sox4-antibody-sox4-2540-protein-microarray-validated-v3874