Specificity Protein 1 Antibody (SP1)

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. [UniProt]

P08047

Rabbit

A portion of amino acids 677-707 from the human protein was used as the immunogen for this SP1 antibody.

Polyclonal

Ig

WB, IHC, FACS, IF, ELISA

Antigen affinity purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the SP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This SP1 antibody is available for research use only.

Primary antibody

https://www.nsjbio.com/tds/sp1-antibody-f41459