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SREBP-1 (phospho Ser439) rabbit pAb

CAT:ES7272-01Size:50 μLPrice:Ask for quotation

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description:

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016],

Synonyms:

SREBF1; BHLHD1; SREBP1; Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1

Gene ID:

6720

UniProt:

P36956

Cellular Locus:

[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane ; Multi-pass membrane protein. Golgi apparatus membrane ; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein. At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed..; [Processed sterol regulatory element-binding protein 1]: Nucleus.; [Isoform SREBP-1aDelta]: Nucleus.; [Isoform SREBP-1cDelta]: Nucleus.

Host:

Rabbit

Species Reactivity:

Human,Rat

Immunogen:

The antiserum was produced against synthesized peptide derived from human SREBP-1 around the phosphorylation site of Ser439. AA range:405-454

Clonality:

Polyclonal

Validated Applications:

WB,IHC,IF,ELISA

Stability:

1 year

Concentration:

1 mg/mL

Dilution:

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Molecular Weight:

122kD

Storage Conditions:

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

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